A few months ago, I shared a post wondering whether thermodynamics might be a better starting point for understanding #ExtracellularVesicle release than the default assumption of intercellular communication.
Since then, this idea has grown into a peer-reviewed perspective published in #JEV :
https://doi.org/10.1002/jev2.70340
The main point is that #EV release represents a regulated, energy-dependent transition within a membrane system maintained far from equilibrium. It is not necessarily a built-in messaging strategy.
Communication can emerge from this process. But it should be demonstrated, not assumed.
The perspective aims to distinguish functional EV-mediated communication from epiphenomenal consequences of vesicle release by asking a simple question:
What quantitative, stoichiometric, kinetic, and energetic criteria need to be met before functional claims become plausible?
I am especially proud of this work because it pushed me to the limits of my scientific thinking and challenged me to reexamine EV biology from broader physical and quantitative perspectives.
#CellBiology #Thermodynamics #ScienceCommunication
